The specific problem we are interested is cognitive dysfunction in Parkinsons disease. Our current research focuses on the influence of dopamine on prefrontal networks controlling cognitive behaviors such as timing and performance monitoring. We combine ensemble recording from populations of neurons in awake, behaving animals with specific manipulations using techniques such as optogenetic stimulation, targeted pharmacology, or selective genetic disruption with RNA interference. We hope to identify new treatment strategies that can be translated to a clinical setting.