The Shen lab seeks to bridge basic science and health services research by exploring the intersection of nature and nurture in mental health. We draw upon tools and perspectives from diverse fields (including neuroscience, genomics, and environmental health) to dissect the complex interplay between genes and the environment. We are especially interested in how early-life and cumulative exposures influence later-life outcomes for mood disorders, psychosis, substance use, and neurodegenerative disorders. By identifying cellular endophenotypes and their molecular correlates, we aim to advance the detection and treatment of neuropsychiatric disorders